Lunatic Fringe

Lunatic Fringe PDF
Author: Allison Moon
Publisher: Lunatic Ink
ISBN: 0983830924
Size: 61.30 MB
Format: PDF, Mobi
Category : Fiction
Languages : en
Pages : 300
View: 3504

Get Book


Lunatic Fringe

by Allison Moon, Lunatic Fringe Books available in PDF, EPUB, Mobi Format. Download Lunatic Fringe books, "A thinking lesbian's werewolf story." - Good Lesbian Books "Enthralling, empowering, and well written." - Curve Magazine Lunatic Fringe indulges the feminine wild by giving the classic werewolf myth a lesbian twist. Lexie Clarion's first night at college, she falls in with a pack of radical feminist werewolf hunters. The next morning, she falls for a mysterious woman who may be among the hunted. As Lexie's new lover and the Pack battle for Lexie's allegiance, the waxing moon illuminates old hatreds, new enemies, and a secret from Lexie's childhood that will change her life forever. Lunatic Fringe is the first book in the Tales of the Pack series.



The Lunatic Fringe

The Lunatic Fringe PDF
Author: William L. DeAndrea
Publisher: Open Road Media
ISBN: 1453290265
Size: 33.21 MB
Format: PDF, Kindle
Category : Fiction
Languages : en
Pages : 282
View: 5905

Get Book


The Lunatic Fringe

by William L. DeAndrea, The Lunatic Fringe Books available in PDF, EPUB, Mobi Format. Download The Lunatic Fringe books, In Old New York, Teddy Roosevelt seeks answers to a cartoonist’s killing, a missing woman, and an impending bomb plot As a newspaper war flares between Joseph Pulitzer and William Randolph Hearst, noted cartoonist Evan Crandall is murdered in his apartment. When police officer Dennis Muldoon finds the body, he also discovers a naked, sultry beauty blindfolded and tied to the bed. She pleads with him to free her, but after he unties this mysterious “Pink Angel,” she steals his gun and escapes. Meanwhile, anarchists are planning to blow up the Croton Reservoir during a millionaire’s nearby wedding reception. Enter the police commissioner, Theodore Roosevelt. With the help of Officer Muldoon, Roosevelt is on a mission to set the city in order, and that will mean putting a stop to escalating crime, and locating the mysterious Pink Angel.



Elucidating The Roles Of Lunatic Fringe In Pancreatic Ductal Adenocarcinoma

Elucidating the Roles of Lunatic Fringe in Pancreatic Ductal Adenocarcinoma PDF
Author: Prathamesh P. Patil
Publisher:
ISBN:
Size: 60.88 MB
Format: PDF
Category :
Languages : en
Pages : 257
View: 2174

Get Book


Elucidating The Roles Of Lunatic Fringe In Pancreatic Ductal Adenocarcinoma

by Prathamesh P. Patil, Elucidating The Roles Of Lunatic Fringe In Pancreatic Ductal Adenocarcinoma Books available in PDF, EPUB, Mobi Format. Download Elucidating The Roles Of Lunatic Fringe In Pancreatic Ductal Adenocarcinoma books, Pancreatic cancer is an aggressive form of cancer that is very difficult to detect, treat resulting in a high rate of mortality. Understanding the molecular basis of pancreatic cancer and identifying new molecular targets for designing therapeutic interventions is paramount for improving outcomes in this disease. Notch signaling is a vital developmental signaling pathway that has been implicated to play both oncogenic and tumor suppressive roles in pancreatic cancer. Previous studies from other groups have shown that O-linked glycosylation of Notch signaling plays a key role in the regulation of Notch signaling. Lunatic fringe (Lfng) is one of the glycosyltransferases that modifies the O-fucosylated Notch receptors. Dysregulation of glycosylation mediated by Lfng has been previously shown to result in several Notch-related developmental disorders. While targeting Notch signaling pathway in cancers has been explored as a potential therapeutic intervention for several cancers, the status of Notch-related glycosylation has not been explored. In the first set of studies, we have characterized the expression pattern of Notch receptors, ligands and Notch-related glycosyltransferases in human pancreatic cancer cell lines and human pancreatic cancer specimens from our Rapid Autopsy Program. These studies identified potential molecular targets in the Notch signaling pathway. Findings of these studies helped identify Lunatic fringe, a Notch-related glycosyltransferase, to have increased expression in human pancreatic cancer. To elucidate the role of Lfng in human pancreatic cancer, we utilized multiple genome editing approaches to engineer three human pancreatic cancer cell lines with a complete lunatic fringe knockout. These cell lines served as model systems to identify the phenotypic changes in pancreatic cancer cells upon loss of functional Lfng gene. Furthermore, we performed next-generation sequencing and polar metabolite analysis to help elucidate the impact of Lfng on the transcriptional and metabolic profile of human pancreatic cancer cell lines. The findings of our study reveal that Lfng impacts the tumorigenicity of pancreatic cancer possibly through global changes in transcription and metabolic reprogramming of cancer cells. These findings of this study provide the basis for further detailed exploration into the role of Notch-related glycosylation in human pancreatic cancer.



The Lunatic Fringe

The Lunatic Fringe PDF
Author: Christopher Collins
Publisher: Createspace Independent Publishing Platform
ISBN: 9781535025881
Size: 66.63 MB
Format: PDF, Kindle
Category :
Languages : en
Pages : 32
View: 3771

Get Book


The Lunatic Fringe

by Christopher Collins, The Lunatic Fringe Books available in PDF, EPUB, Mobi Format. Download The Lunatic Fringe books, A GAY MAN with the ability to inhabit other peoples' bodies has affairs with a STRAIGHT MAN around the world while enjoying a wonderful relationship with his GAY PARTNER.



The Lunatic Fringe

The Lunatic Fringe PDF
Author: Gerald White Johnson
Publisher: Praeger
ISBN:
Size: 65.80 MB
Format: PDF, ePub
Category : Biography & Autobiography
Languages : en
Pages : 248
View: 4384

Get Book


The Lunatic Fringe

by Gerald White Johnson, The Lunatic Fringe Books available in PDF, EPUB, Mobi Format. Download The Lunatic Fringe books, Le dernier rapport biennal du Centre international de Recherche sur le Cancer (CIRC), la branche de recherche sur le cancer de l'Organisation mondiale de la Sant, passe en revue un grand nombre de projets de recherche. La plupart refltent des collaborations scientifiques avec des instituts du cancer du monde entier, et couvrent un ventail de recherche allant de l'pidmiologie descriptive et de la biostatistique l'enregistrement du cancer et de l'analyse des donnes sur l'incidence du cancer la recherche fondamentale sur les aspects gntiques et molculaires du dveloppement du cancer ou encore aux tudes de la pathologie ou de la prvention. Ce rapport est gnreusement illustr, et dcrit galement le personnel du Centre, sa structure et ses activits, et donne en outre la liste bibliographique complte des plus de 500 publications et articles publis par ses chercheurs et leurs collaborateurs tout au long de cet exercice biennal 2006-2007.



The Origin And Fate Of Somites

The Origin and Fate of Somites PDF
Author: North Atlantic Treaty Organization. Scientific Affairs Division
Publisher: IOS Press
ISBN: 9781586030933
Size: 19.28 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 245
View: 6287

Get Book


The Origin And Fate Of Somites

by North Atlantic Treaty Organization. Scientific Affairs Division, The Origin And Fate Of Somites Books available in PDF, EPUB, Mobi Format. Download The Origin And Fate Of Somites books, This text investigates advances in the field of sommites and integrates them into the accumulated knowledge of how sommites form and differentiate. Although the book focuses on the formation and patterning of somites it will encompass a broader life history of a somite. Topics include events attending gastrulation, which foreshadow somite formation, to the subsequent contributions that somites make to neighbouring regions such as musculature, limbs and axial skeleton. There is also a discussion of the origins of cells that eventually give rise to somites. This book brings together investigators from NATO and NATO partner countries who are employing both classical and molecular approaches to the analysis of somitogenesis.



Right Is Wrong

Right is Wrong PDF
Author: Arianna Stassinopoulos Huffington
Publisher: Knopf
ISBN:
Size: 28.46 MB
Format: PDF, Mobi
Category : Political Science
Languages : en
Pages : 388
View: 4186

Get Book


Right Is Wrong

by Arianna Stassinopoulos Huffington, Right Is Wrong Books available in PDF, EPUB, Mobi Format. Download Right Is Wrong books, Arguing that the Republican Party is promoting an agenda at odds with the views of the majority of the American people, the author tackles key issues for the 2008 presidential election and calls for the establishment of a new, progressive national agenda.



Buzz

Buzz PDF
Author: Marian Salzman
Publisher: John Wiley & Sons
ISBN: 9780471273455
Size: 32.11 MB
Format: PDF, ePub, Docs
Category : Business & Economics
Languages : en
Pages : 256
View: 2713

Get Book


Buzz

by Marian Salzman, Buzz Books available in PDF, EPUB, Mobi Format. Download Buzz books, How to master the power of buzz Trendspotters and bestselling authors Marian Salzman and Ira Matathia demystify buzz and show how marketers can create and leverage it for the success of their products and services. The world we inhabit is in constant flux, and the captive audience on which advertisers relied for years no longer exists. Branding today requires a flexibility and creativity that have thus far eluded many traditional practitioners. When there is no clear forum for communicating your brand message to the audience, you must have your audience do it for you. The authors show how and why buzz works, examining case studies like Kate Spade, Madonna, Bulgari, Ford, Nokia, and French Connection. They explore the role specific consumer groups play in setting trends, show how influence works, reveal the efficacy of shock ads, and explain how to manage brand momentum. This book is a dynamic guide that sheds new light on the topic of buzz using real-world examples and case studies that show how marketers can manufacture the seemingly authentic word-of-mouth to which today's cynical consumer responds.



Wwe Vol 2

WWE Vol  2 PDF
Author: Dennis Hopeless
Publisher: BOOM! Studios
ISBN: 9781684150625
Size: 77.34 MB
Format: PDF, Mobi
Category : Comics & Graphic Novels
Languages : en
Pages : 112
View: 4485

Get Book


Wwe Vol 2

by Dennis Hopeless, Wwe Vol 2 Books available in PDF, EPUB, Mobi Format. Download Wwe Vol 2 books, Continuing the Shield trilogy, WWE Volume 2 follows the most unhinged former member of The Shield: Dean Ambrose. Dean Ambrose is bluecollar toughness personified. He’s not the biggest guy in the ring. He’s not the strongest. But you have another thing coming if you expect him to stay down. If that were all, that would be enough. But Dean Ambrose is also known as the Lunatic Fringe and naturally he’s going to run into trouble while on the road traveling from one gig to another. Dean may have bitten off more than he can chew when he finds himself face-to-face with the beast incarnate Brock Lesnar on the path to WrestleMania. Welcome to Suplex City, Dean. Enjoy your stay.



Fiction On The Fringe

Fiction on the Fringe PDF
Author: Grammatiki A. Karla
Publisher: BRILL
ISBN: 9004175474
Size: 40.90 MB
Format: PDF, Docs
Category : Literary Criticism
Languages : en
Pages : 194
View: 5364

Get Book


Fiction On The Fringe

by Grammatiki A. Karla, Fiction On The Fringe Books available in PDF, EPUB, Mobi Format. Download Fiction On The Fringe books, This collection of essays offers a comprehensive examination of texts that traditionally have been excluded from the main corpus of the ancient Greek novel and confined to the margins of the genre, such as the Life of Aesop, the Life of Alexander the Great, and the Acts of the Christian Martyrs. Through comparison and contrast, intertextual analysis and close examination, the boundaries of the dichotomy between the fringe vs. the canonical or erotic novel are explored, and so the generic identity of the texts in each group is more clearly outlined. The collective outcome brings the fringe from the periphery of scholarly research to the centre of critical attention, and provides methodological tools for the exploration of other fringe texts.