The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging PDF
Author: Andre S. Merbach
Publisher: John Wiley & Sons
ISBN: 1118503678
Size: 62.45 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 512
View: 1126

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The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging

by Andre S. Merbach, The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging Books available in PDF, EPUB, Mobi Format. Download The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging books, Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine



The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging PDF
Author: André E. Merbach
Publisher: Wiley
ISBN: 9780471607786
Size: 63.35 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 484
View: 2929

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The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging

by André E. Merbach, The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging Books available in PDF, EPUB, Mobi Format. Download The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging books, There has been a huge increase in the use of MRI and contrast agents in medicine in recent years as evidenced by a big increase in the number of hospitals with MRI machines and the ever-increasing number of examinations using contrast agents. Contrast agents have revolutionized the use of Magnetic Resonance Imaging (MRI) in medical diagnostics, allowing doctors to distinguish between normal and abnormal tissues and ultimately improving prognosis for the patient. This monograph covers all aspects of production, use, operating mechanisms and theory of these diagnostic agents, used to produce high contrast images in MRI. It will therefore be unique resource for what is currently a very active domain of research both in universities and in industry. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging is a comprehensive treatise: * written by the most active scientists in the field of contrast agents for medical MRI - from both university and industrial backgrounds * covering the topic from every angle from synthesis to safety considerations * invaluable to physicists, chemists, biologists as well as physicians * the first in-depth coverage of this topic



Contrast Agents I

Contrast Agents I PDF
Author: Werner Krause
Publisher: Springer
ISBN: 354045733X
Size: 19.49 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 249
View: 5962

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Contrast Agents I

by Werner Krause, Contrast Agents I Books available in PDF, EPUB, Mobi Format. Download Contrast Agents I books, Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].



High Relaxivity Mri Contrast Agents

High Relaxivity MRI Contrast Agents PDF
Author:
Publisher:
ISBN:
Size: 77.85 MB
Format: PDF, ePub, Mobi
Category :
Languages : en
Pages :
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High Relaxivity Mri Contrast Agents

by , High Relaxivity Mri Contrast Agents Books available in PDF, EPUB, Mobi Format. Download High Relaxivity Mri Contrast Agents books, The desire to improve and expand the scope of clinical magnetic resonance imaging (MRI) has prompted the search for contrast agents of higher efficiency. The development of better agents requires consideration of the fundamental coordination chemistry of the gadolinium(III) ion and the parameters that affect its efficacy as a proton relaxation agent. In optimizing each parameter, other practical issues such as solubility and in vivo toxicity must also be addressed, making the attainment of safe, high-relaxivity agents a challenging goal. Here we present recent advances in the field, with an emphasis on the hydroxypyridinone family of Gd{sup III} chelates.



The Chemistry Of Molecular Imaging

The Chemistry of Molecular Imaging PDF
Author: Nicholas Long
Publisher: John Wiley & Sons
ISBN: 1118854772
Size: 79.24 MB
Format: PDF, ePub
Category : Technology & Engineering
Languages : en
Pages : 408
View: 459

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The Chemistry Of Molecular Imaging

by Nicholas Long, The Chemistry Of Molecular Imaging Books available in PDF, EPUB, Mobi Format. Download The Chemistry Of Molecular Imaging books, Molecular imaging is primarily about the chemistry of novelbiological probes, yet the vast majority of practitioners are notchemists or biochemists. This is the first book, written from achemist's point of view, to address the nature of the chemicalinteraction between probe and environment to help elucidatebiochemical detail instead of bulk anatomy. Covers all of the fundamentals of modern imaging methodologies,including their techniques and application within medicine andindustry Focuses primarily on the chemistry of probes and imagingagents, and chemical methodology for labelling andbioconjugation First book to investigate the chemistry of molecularimaging Aimed at students as well as researchers involved in the areaof molecular imaging



Medizinische Physik

Medizinische Physik PDF
Author: Wolfgang Schlegel
Publisher: Springer-Verlag
ISBN: 3662548011
Size: 72.33 MB
Format: PDF, Mobi
Category : Science
Languages : de
Pages : 726
View: 3667

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Medizinische Physik

by Wolfgang Schlegel, Medizinische Physik Books available in PDF, EPUB, Mobi Format. Download Medizinische Physik books, Das vorliegende Werk bietet eine im deutschsprachigen Raum einzigartige, umfassende und aktuelle Darstellung der Medizinischen Physik. Es liefert damit das Fundament für die Anwendung physikalischer Methoden in der Medizin, der Entwicklung neuer oder verbesserter Verfahren zur Untersuchung und Behandlung von Patienten sowie für die Bereitstellung und den Einsatz physikalischer Methoden in der klinischen Anwendung. Es unterstützt als Lehrbuch den Bedarf nach einer systematischen medizinphysikalischen Aus- und Weiterbildung von Physikern, die an medizinischen Einrichtungen tätig sind. Das Buch orientiert sich am Stoffkatalog der Deutschen Gesellschaft für Medizinische Physik (DGMP) und legt den Schwerpunkt auf die Medizinische Physik in der Radiologie und Radioonkologie. Das Werk ist in fünf Teile unterteilt: · In Teil I werden die Grundlagen der Strahlenphysik, der biostatistischen Methoden, der Medizinischen Informatik, der organisatorischen und rechtlichen Aspekte sowie des Strahlenschutzes abgehandelt. · Teil II behandelt die radiologische Diagnostik und umfasst die bildgebenden Verfahren der Röntgendiagnostik, der Röntgen-Computertomographie, der Magnetresonanztomographie sowie des Ultraschalls. · Teil III beschreibt die Methoden der nuklearmedizinischen Diagnostik und Therapie. · In Teil IV wird die Medizinische Physik der Strahlentherapie in vertiefter Form dargestellt. · Teil V beschreibt ausgewählte Themen aus dem Gebiet der Medizintechnik. Zu allen Teilen werden Übungsaufgaben und Kontrollfragen angeboten, mit denen der Leser das Gelernte überprüfen kann. Ergänzend werden auf einer Website Musterlösungen, zusätzliches vertiefendes Text- und Bildmaterial sowie Animationen und Videos zur Verfügung gestellt. Das Buch versteht sich als Lehrbuch und Nachschlagewerk, das begleitend zu Weiterbildungsveranstaltungen und Studiengängen oder auch zum Selbststudium auf dem Gebiet der Medizinischen Physik eingesetzt werden kann. Es basiert auf dem Heidelberger Weiterbildungskurs „Medizinische Physik für Physiker“ und richtet sich vornehmlich an Physik-Absolventen und Naturwissenschaftler mit grundlegenden physikalischen Kenntnissen. Die Herausgeber sind als Wissenschaftler am Deutschen Krebsforschungszentrum (dkfz) tätig und lehren als Professoren für Medizinische Physik an der Universität Heidelberg.



The Chemistry Of Imaging Probes

The Chemistry of Imaging Probes PDF
Author: Lorenzo Tei
Publisher: Frontiers Media SA
ISBN: 288945598X
Size: 61.39 MB
Format: PDF, ePub
Category :
Languages : en
Pages : 129
View: 6969

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The Chemistry Of Imaging Probes

by Lorenzo Tei, The Chemistry Of Imaging Probes Books available in PDF, EPUB, Mobi Format. Download The Chemistry Of Imaging Probes books, Over the past decades, the field of molecular imaging has been rapidly growing involving multiple disciplines such as medicine, biology, chemistry, pharmacology and biomedical engineering. Any molecular imaging procedure requires an imaging probe that is an agent used to visualize, characterize and quantify biological processes in living systems. Such a probe typically consists of an agent that usually produces signal for imaging purpose, a targeting moiety, and a linker connecting the targeting moiety and the signaling agent. Many challenging problems of molecular imaging can be addressed by exploiting the great possibilities offered by modern synthetic organic and coordination chemistry and the powerful procedures provided by conjugation chemistry. Thus, chemistry plays a decisive role in the development of this cutting-edge methodology. Currently, the diagnostic imaging modalities include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasound (US), Nuclear Imaging (PET, SPECT), Optical Imaging (OI) and Photoacoustic Imaging (PAI). Each of these imaging modalities has its own advantages and disadvantages, and therefore, a multimodal approach combining two techniques is often adopted to generate complementary anatomical and functional information of the disease. The basis for designing imaging probes for a given application is dictated by the chosen imaging modality, which in turn is dependent upon the concentration and localization profile (vascular, extracellular matrix, cell membrane, intracellular, near or at the cell nucleus) of the target molecule. The development of high-affinity ligands and their conjugation to the targeting vector is also one of the key steps for pursuing efficient molecular imaging probes. Other excellent reviews, text and monographs describe the principles of biomedical imaging, focusing on molecular biology or on the physics behind the techniques. This Research Topic aims to show how chemistry can offer molecular imaging the opportunity to express all its potential.



Micro And Nanotechnology In Vaccine Development

Micro  and Nanotechnology in Vaccine Development PDF
Author: Mariusz Skwarczynski
Publisher: William Andrew
ISBN: 0323400299
Size: 45.90 MB
Format: PDF
Category : Medical
Languages : en
Pages : 460
View: 4873

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Micro And Nanotechnology In Vaccine Development

by Mariusz Skwarczynski, Micro And Nanotechnology In Vaccine Development Books available in PDF, EPUB, Mobi Format. Download Micro And Nanotechnology In Vaccine Development books, This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines



New Applications Of Nmr In Drug Discovery And Development

New Applications of NMR in Drug Discovery and Development PDF
Author: Leoncio Garrido
Publisher: Royal Society of Chemistry
ISBN: 1849737665
Size: 53.86 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 304
View: 1506

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New Applications Of Nmr In Drug Discovery And Development

by Leoncio Garrido, New Applications Of Nmr In Drug Discovery And Development Books available in PDF, EPUB, Mobi Format. Download New Applications Of Nmr In Drug Discovery And Development books, This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods in NMR, many of which are not widely applied but are likely to provide new opportunities for drug design. The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and interaction with targets. Particular emphasis is put on applications with unexploited potential for drug discovery and development. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity. Aimed at NMR spectroscopists and pharmaceutical scientists, this title will be invaluable at putting NMR within context in its role in drug discovery and development. This resource will be essential reading for those both new and already active in these areas.



Introduction To Modern Inorganic Chemistry 6th Edition

Introduction to Modern Inorganic Chemistry  6th edition PDF
Author: R.A. Mackay
Publisher: CRC Press
ISBN: 9780748764204
Size: 52.61 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 624
View: 3616

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Introduction To Modern Inorganic Chemistry 6th Edition

by R.A. Mackay, Introduction To Modern Inorganic Chemistry 6th Edition Books available in PDF, EPUB, Mobi Format. Download Introduction To Modern Inorganic Chemistry 6th Edition books, This popular and comprehensive textbook provides all the basic information on inorganic chemistry that undergraduates need to know. For this sixth edition, the contents have undergone a complete revision to reflect progress in areas of research, new and modified techniques and their applications, and use of software packages. Introduction to Modern Inorganic Chemistry begins by explaining the electronic structure and properties of atoms, then describes the principles of bonding in diatomic and polyatomic covalent molecules, the solid state, and solution chemistry. Further on in the book, the general properties of the periodic table are studied along with specific elements and groups such as hydrogen, the 's' elements, the lanthanides, the actinides, the transition metals, and the "p" block. Simple and advanced examples are mixed throughout to increase the depth of students' understanding. This edition has a completely new layout including revised artwork, case study boxes, technical notes, and examples. All of the problems have been revised and extended and include notes to assist with approaches and solutions. It is an excellent tool to help students see how inorganic chemistry applies to medicine, the environment, and biological topics.